De Pantaleonibus Palace covers a wide area in the city of Nardò. It is located on the border of the three neighborhoods: the San Salvatore, the Castelli Veteris and Sant'Angelo ones.

The palace was probably built between the end of the 16th century and the beginning of the 17th century. Part of the palace currently belongs to the Giuri family and the remainder to the English family Stacey which started to completely restore it respecting its original historical and artistic shape.